Direct chromosome-length haplotyping by single-cell sequencing
نویسندگان
چکیده
منابع مشابه
Direct chromosome-length haplotyping by single-cell sequencing.
Haplotypes are fundamental to fully characterize the diploid genome of an individual, yet methods to directly chart the unique genetic makeup of each parental chromosome are lacking. Here we introduce single-cell DNA template strand sequencing (Strand-seq) as a novel approach to phasing diploid genomes along the entire length of all chromosomes. We demonstrate this by building a complete haplot...
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Haplotypes are fundamental to fully characterize the diploid genome of an individual, yet methods to directly chart the unique genetic makeup of each parental chromosome are lacking. Here we introduce single cell DNA template strand sequencing (Strand-seq) as a novel approach to phase diploid genomes along the entire length of all chromosomes. We demonstrate this by building a complete haplotyp...
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ژورنال
عنوان ژورنال: Genome Research
سال: 2016
ISSN: 1088-9051,1549-5469
DOI: 10.1101/gr.209841.116